Deglycosylated kringle 1-3 region fragments of plasminogen and methods of use
US7157556B1 · kind B1 · utility
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20Claims
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Key dates
| Filing date | Feb 10, 2000 |
| Grant date | Jan 2, 2007 |
| Priority date | — |
| Expiry date | Feb 10, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y304/21007
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed are deglycosylated fragments of a kringle 1-3 region of plasminogen, nucleotides encoding deglycosylated kringle 1-3 region proteins and antibodies specific for deglycosylated kringle 1-3 region proteins. The compositions of the present invention have increased antiangiogenic activity as compared to previously isolated kringle 1-3 region proteins. Also included in the present invention are methods of treating angiogenesis-associated diseases and conditions such as cancer using the compositions described herein.
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