Direct selection of cells by secretion product

US7166423B1 · kind B1 · utility

Assignee

• Miltenyi Biotec, Inc. · DE

Inventors

• Stefan Miltenyi · Wittlich, DE
• Andreas Radbruch · Bonn, DE
• Rudi Manz · Linz, DE

Key dates

• Filing date: Oct 21, 1993
• Grant date: Jan 23, 2007
• Expiry date: Oct 21, 2013

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S436/824
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Cells can be labeled with products which they secrete and release in an efficient manner by coupling the cells at their surface to a specific binding partner for the product and allowing the product to be captured by the specific binding partner as it is secreted and released. The product-labeled cells can then be further coupled to suitable labels, if desired, and separated according to the presence, absence, or amount of product.