Synthetic heparin-binding growth factor analogs

US7166574B2 · kind B2 · utility

Assignees

• BioSurface Engineering Technologies, Inc. · US
• Brookhaven National Laboratory · US

Inventors

• Louis A. Pena · Poquott, US
• Paul O. Zamora · Gaithersburg, US
• Xinhua Lin · Plainview, US
• John D. Glass · Shoreham, US

Key dates

• Filing date: Aug 20, 2002
• Grant date: Jan 23, 2007
• Expiry date: Nov 27, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides synthetic heparin-binding growth factor analogs having at least one peptide chain that binds a heparin-binding growth factor receptor, covalently bound to a hydrophobic linker, which is in turn covalently bound to a non-signaling peptide that includes a heparin-binding domain. The synthetic heparin-binding growth factor analogs are useful as soluble biologics or as surface coatings for medical devices.