Hydroxyindoles, their use as inhibitors of phosphodiesterase 4, and processes for preparing them

US7166637B2 · kind B2 · utility

Assignee

• elbion GmbH · DE

Inventors

• Norbert Höfgen · Radeberg, DE
• Hildegard Kuss · Dresden, DE
• Ute Egerland · Radebeul, DE
• Chris Rundfeldt · Coswig, DE
• Helge Hartenhauer · Dresden, DE
• Antje Gasparic · Coswig, DE

Key dates

• Filing date: Nov 13, 2003
• Grant date: Jan 23, 2007
• Expiry date: Sep 29, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D209/22
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to substituted 4- or/and 7-hydroxyindoles, to processes for preparing them, to pharmaceutical preparations which comprise these compounds and to the pharmaceutical use of these compounds, which are inhibitors of phosphodiesterase 4, as active compounds for treating diseases which can be influenced by using the compounds according to the invention to inhibit phosphodiesterase 4 activity in immunocompetent cells (e.g. macrophages and lymphocytes).