Process for the extraction of paclitaxel and 9-dihydro-13-acetylbaccatin III from Taxus
US7169307B2 · kind B2 · utility
Inventor
Key dates
| Filing date | Sep 2, 2004 |
| Grant date | Jan 30, 2007 |
| Priority date | — |
| Expiry date | Jan 1, 2025 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01D15/426
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
This invention teaches a purification technology to extract an organic solution of paclitaxel by using a “Load and Lock Axial Compression Column” for industrial scale preparative high performance liquid chromatography. The “Load and Lock Axial Compression Column” is one in which a piston is used to pack and unpack the chromatography bed substantially to avoid voids therein, and to maintain bed compression during use. This effectively substantially prevents the formation of voids in the bed. The column can be packed with any packing material, including small particle size (e.g., about 10 μm) media, and very high plate numbers are generated. The bed length can be adjusted by controlling the amount of packing material used to prepare the column.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.