Electrochemical detection of nucleic acid sequences

US7169358B2 · kind B2 · utility

Inventors

• Robert W. Henkens · Durham, US
• John P. O'Daly · Carrboro, US
• Marek Wojciechowski · Cary, US
• Honghua Zhang · San Diego, US
• Najih Naser · Cary, US
• R. Michael Roe · Apex, US
• Thomas N. Stewart · Durham, US
• Deborah M. Thompson · Raleigh, US
• Rebecca Sundseth · Durham, US
• Steven E. Wegner · Chapel Hill, US

Key dates

• Filing date: Feb 25, 2002
• Grant date: Jan 30, 2007
• Expiry date: Jan 3, 2023

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

An electrochemical detection system which specifically detects selected nucleic acid segments is described. The system utilizes biological probes such as nucleic acid or peptide nucleic acid probes which are complementary to and specifically hybridize with selected nucleic acid segments in order to generate a measurable current when an amperometric potential is applied. The electrochemical signal can be quantified.