Device for determining a glucose concentration in a tissue fluid

US7169600B2 · kind B2 · utility

Assignee

• Roche Diagnostics GMBH · DE

Inventors

• Udo Hoss · Ulm, DE
• Hans-Joerg Pfleiderer
• Ralf Gessler · Weingarten, DE
• Hans-Ulrich Zieten · Illerrieden, DE
• Rolf Fussgaenger · Blaustein, DE

Key dates

• Filing date: Feb 19, 2004
• Grant date: Jan 30, 2007
• Expiry date: May 11, 2025

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61B5/14532
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

The invention concerns an arrangement for determining the concentration of glucose in a tissue fluid. In the microdialysis technology used for this purpose, perfusate-containing glucose is transported in intermittent delivery pulses through a microdialysis probe inserted into the tissue fluid and dialysate obtained in this process is passed to a measuring cell to record the glucose content. In order to achieve an exact determination of glucose even with a reduced dialysis period, it is proposed that the starting content of glucose in the perfusate is adapted to the glucose content of the tissue fluid by means of a control device in accordance with a command variable derived from the measurement signals of the measuring cell. When the control deviation is negligible the momentary starting content of glucose in the perfusate can be determined as a measure for the glucose content of the tissue fluid.