Method for PR-39 peptide mediated selective inhibition of IκBα degradation
US7169604B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Dec 29, 1999 |
| Grant date | Jan 30, 2007 |
| Priority date | — |
| Expiry date | Dec 29, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/1709
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides both a method and means for regulating IκBα degradation, NFκB activity, and NFκB-dependent gene expression within living cells, tissues, and organs in-situ. The selective regulation is performed using native PR-39 peptide or one of its shorter-length homologs, for interaction with such IκBα and proteasomes as are present in the cytoplasm of viable cells. The result of PR-39 peptide interaction with IκBα is a selective alteration in the intracellular proteolytic activity of proteasomes, which in turn, causes a reduction of IκBα, a decrease of NFκB activity, and a down-regulation of NFκB-dependent gene expression.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.