5-substituted 2-aryl-4-pyrimidinones
US7169790B2 · kind B2 · utility
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10References
32Claims
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Key dates
| Filing date | Jun 7, 2005 |
| Grant date | Jan 30, 2007 |
| Priority date | — |
| Expiry date | Jun 7, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D239/52
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Arylpyrimidinone compounds that act as selective modulators of CRF 1 receptors are provided. These compounds are useful in the treatment of a number of CNS and periphereal disorders, particularly stress, anxiety, depression, cardiovascular disorders, and eating disorders. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided.Compounds of the invention are also useful as probes for the localization of CRF receptors and as standards in assays for CRF receptor binding. Methods of using the compounds in receptor localization studies are given.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.