Guanidinium transport reagents and conjugates

US7169814B2 · kind B2 · utility

Assignees

• The Board of Trustees of the Leland Stanford Junior University · US
• Cellgate, Inc. · US

Inventors

• Jonathan B. Rothbard · Woodside, US
• Paul A. Wender · Menlo Park, US
• Kanaka Pattabiraman · Los Altos, US
• Erin Pelkey · Phelps, US
• Theodore C. Jessop · Lawrenceville, US

Key dates

• Filing date: Dec 11, 2002
• Grant date: Jan 30, 2007
• Expiry date: Jul 29, 2023

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Transport reagents and conjugates of therapeutic agents linked to transport reagents are described. In particular, the transport reagents have a plurality of guanidinium moieties that are either contiguous or spaced along a backbone, but are sufficiently removed from the backbone via tethers, to allow their interaction with a cell or tissue surface, leading to uptake of the therapeutic agent.