Non-imidazole alkylamines as histamine H3-receptor ligands and their therapeutic applications

US7169928B2 · kind B2 · utility

Assignee

• Bioproject · FR

Inventors

• Jean-Charles Schwartz · Paris, FR
• Jean-Michel Arrang · Gif-sur-Yvette, FR
• Monique Garbarg · Paris, FR
• Jeanne-Marie Lecomte · Paris, FR
• Xavier Ligneau · Brive-la-Gaillarde, FR
• Walter Schunack · Berlin, DE
• Holger Stark · Bad Homburg vor der Höhe, DE
• Charon R. Ganellin · Welwyn Garden City, GB
• Fabien Leurquin · London, GB
• Sigurd Elz · Berlin, DE

Key dates

• Filing date: Jun 1, 2004
• Grant date: Jan 30, 2007
• Expiry date: Dec 6, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2602/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Use of a compound of formula (A), wherein:W is a residue which imparts antagonistic and/or agonistic activity at histamine H3-receptors when attached to an imidazole ring in 4(5) position; R1 and R2 may be identical or different and represent each independently a lower alkyl or cycloalkyl, or taken together with the nitrogen atom to which they are attached, a saturated nitrogen-containing ring (i) as defined, a non-aromatic unsaturated nitrogen-containing ring (ii) as defined, a morpholino group, or a N-substituted piperazino group as defined for preparing medicaments acting as antagonists and/or agonists at the H3-receptors of histamine.