Indolinone derivatives substituted in the 6-position, their preparation and their use as medicaments

US7169936B2 · kind B2 · utility

Assignee

• BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG · DE

Inventors

• Gerald Juergen Roth · Biberach, DE
• Armin Heckel · Biberach an der Riß, DE
• Thorsten Lehmann-Lintz · Ochsenhausen, DE
• Joerg Kley · Mittelbiberach, DE
• Frank Hilberg · Wien, AT
• Jacobus Van Meel · Biberach, DE
• Ulrike Tontsch-Grunt · Baden, AT

Key dates

• Filing date: Jul 22, 2003
• Grant date: Jan 30, 2007
• Expiry date: Sep 18, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to indolinone derivatives, substituted in the 6-position, of the formulain whichR1 to R6 and X are as defined in claim 1, to their tautomers, enantiomers, diastereomers, to their mixtures and to their salts, in particular their physiologically acceptable salts, which have useful pharmacological properties, in particular in inhibiting action on various receptor tyrosine kinases and on the proliferation of endothelial cells and various tumour cells, to medicaments comprising these compounds, to their use and to processes for their preparation.