System and method for optimizing tissue barrier transfer of compounds
US7172859B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 20, 2003 |
| Grant date | Feb 6, 2007 |
| Priority date | — |
| Expiry date | Mar 24, 2023 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N13/00
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention relates to high-throughput systems and methods to prepare a large number of component combinations, at varying concentrations and identities, at the same time, and high-throughput methods to test tissue barrier transfer, such as transdermal transfer, of components in each combination. The methods of the present invention allow determination of the effects of inactive components, such as solvents, excipients, enhancers, adhesives and additives, on tissue barrier transfer of active components, such as pharmaceuticals. The invention thus encompasses the high-throughput testing of pharmaceutical compositions or formulations in order to determine the overall optimal composition or formulation for improved tissue transport, such as transdermal transport.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.