Hypoglycaemic peptides and methods of use thereof
US7173012B2 · kind B2 · utility
0Cited by
4References
9Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Jun 27, 2002 |
| Grant date | Feb 6, 2007 |
| Priority date | — |
| Expiry date | Sep 14, 2022 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A peptide of the formula (Xaa)n1-Xaa1-His-Thr-Asp-(Xaa)n2, wherein Xaa is any amino acid; Xaa1 is a hydrophobic amino acid, preferably Gly or Val; n1 is 0–10; and n2 is 0–10; and use thereof in regulating in vivo blood glucose levels in a human or other mammal, particularly in the treatment of Type 2 diabetes in a human. Preferably, the peptide is a tetrapeptide selected from Gly-His-Thr-Asp and Val-His-Thr-Asp. These hypoglycaemic peptides are isolated from human urine and they also have been chemically synthesized.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.