Patent · US Expired

Monoclonal antibodies against ricin toxin and methods of making and using thereof

US7175845B2 · kind B2 · utility

3Cited by
2References
7Claims
0Family size

Assignee

Inventor

Key dates

Filing dateJul 23, 2004
Grant dateFeb 13, 2007
Priority date—
Expiry dateOct 8, 2024

Classification

  • Technology area (CPC G)Physics
  • CPC primaryG01N2333/924
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

Disclosed herein are monoclonal antibodies (Mabs) against ricin toxin and its subunits. The Mabs were initially selected based upon their ability to bind to ricin and its individual subunits in a solid-phase enzyme-linked immunoassay (ELISA). Several candidates were selected for further evaluation, including their ability to inhibit ricin intoxication in vitro and for their utility as immunodiagnostic reagents. As disclosed herein, the Mabs may be used in immunoassays. Also disclosed, are use of the Mabs to inhibit ricin-mediated eukaryotic cell cytotoxicity in vitro, thereby indicating that these Mabs may be used to prevent and treat ricin intoxication in vivo. Kits comprising the Mabs are also disclosed.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.