Modified corin molecules having substitute activation sequences and uses thereof
US7176013B2 · kind B2 · utility
1Cited by
4References
22Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Jun 9, 2004 |
| Grant date | Feb 13, 2007 |
| Priority date | — |
| Expiry date | Sep 10, 2024 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/975
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention relates to novel modified corin molecules, or fragments or derivatives thereof, comprising a substitute activation sequence. The modified corin molecules are cleaved at the substitute activation sequence, thereby generating activated corin molecules, or fragments or derivatives thereof, that exhibit the functional activity of naturally occurring, wild-type corin molecules. The modified corin molecules can be used to treat a variety of diseases or disorders, including congestive heart failure and acute myocardial infarction.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.