Biocompatible crosslinked composition

US7176256B2 · kind B2 · utility

Assignee

• Angiotech Pharmaceuticals, Inc. · CA

Inventors

• Woonza M. Rhee · Palo Alto, US
• Frank DeLustro · Belmont, US
• Richard A. Berg · Los Altos, US

Key dates

• Filing date: Jun 21, 2004
• Grant date: Feb 13, 2007
• Expiry date: Jun 21, 2024

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S623/901
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

Crosslinked polymer compositions comprise a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene glycol that has been modified to contain multiple nucleophilic groups, such as primary amino (—NH2)or thiol (—SH) groups. The second synthetic polymer may be a hydrophilic or hydrophobic synthetic polymer which contains, or has been derivatized to contain, two or more electrophilic groups, such as succinimidyl groups. The compositions may further comprise other components, such as naturally occurring polysaccharides or proteins (such as glycosaminoglycans or collagen) and/or biologically active agents. Also disclosed are methods for using the crosslinked polymmer compositions to effect adhesion between a first surface and a second surface; to effect tissue augmentation; to prevent the formation of surgical adhesions; and to coat a surface of a synthetic implant.