Tools for the diagnosis and treatment of Alzheimer's disease

US7176290B2 · kind B2 · utility

Assignee

• Max-Planck-Gesellschaft zur Föderung der Wissenschaften e.V. · US

Inventors

• Eva-Marie Mandelkow · Hamburg, DE
• Eckhard Mandelkow · Hamburg, DE
• Birgit Lichtenberg-Kraag · Prenzlau, DE
• Jacek Biernat · Hamburg, DE
• Gerard Drewes · Hamburg, DE
• Barbara Steiner · Ludwigshafen, DE

Key dates

• Filing date: Feb 4, 2002
• Grant date: Feb 13, 2007
• Expiry date: Feb 4, 2022

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/2821
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to phosphorylated tau protein epitopes associated with Alzheimer's disease, to protein kinases responsible for tau protein epitope phosphorylation, and to antibodies specific for the tau epitopes. Additionally, the present invention relates to pharmaceutical compositions, methods for detection, and methods of testing drugs effective in dissolving paired helical filaments associated with Alzheimer's disease.