Compositions and methods to enhance sensitivity of cancer cells to mitotic stress
US7176293B1 · kind B1 · utility
1Cited by
2References
23Claims
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Key dates
| Filing date | Jun 14, 2000 |
| Grant date | Feb 13, 2007 |
| Priority date | — |
| Expiry date | May 23, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/4702
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
An isolated nucleic acid sequence of a mitotic checkpoint gene, chfr, encodes a Chfr protein having a Forkhead-associated domain and a Ring Finger. This protein is required for regulation of the transition of cells from prophase to metaphase during mitosis. The chfr nucleic acid and Chfr polypeptide are useful in diagnosing tumorigenic cells and in screening for drugs which can inhibit the activity of Chfr in a cancer cell, thereby rendering the cell more sensitive to additional anti-tumor therapies.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.