Methods for in vivo evaluation of pulmonary physiology and/or function using NMR signals of polarized Xe
US7179450B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jan 31, 2003 |
| Grant date | Feb 20, 2007 |
| Priority date | — |
| Expiry date | Nov 18, 2023 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01R33/563
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
In certain embodiments, methods of the present invention obtain dynamic data sets of an NMR spectroscopy signal of polarized 129Xe in a selected structure, environment, or system. The signal data can be used to evaluate: (a) the physiology of a membrane or tissue; (b) the operational condition or function of a body system or portion thereof (when at rest or under stimulation); and/or (c) the efficacy of a therapeutic treatment used to treat a diagnosed disorder, disease, or condition. Thus, the present invention provides methods for screening and/or diagnosing a respiratory, cardiopulmonary disorder or disease such as chronic heart failure, and/or methods for monitoring the efficacy of therapeutics administered to subject to treat the disorder or disease.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.