Estrogen receptor site-specific ribozymes and uses thereof for estrogen dependent tumors

US7179593B1 · kind B1 · utility

Assignee

• The Board of Regents of the University of Texas System · US

Inventors

• Arun K. Roy · San Antonio, US
• Yan Lavrovsky · San Diego, US
• Rakesh K. Tyagi · New Delhi, IN
• Chung S. SONG · San Antonio, US
• Bandana Chatterjee · San Antonio, US
• Shuo Chen · Beijing, CN

Key dates

• Filing date: Jun 2, 2000
• Grant date: Feb 20, 2007
• Expiry date: Mar 2, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/158
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Highly specific hammerhead ribozymes are provided that human target estrogen receptor mRNA. These ribozymes, designated RZ1 through RZ7 provide predictable mRNA cleavage products. Methods for inhibiting estrogen-dependent tumor growth, such as that characteristic of breast cancer, are also provided employing these ribozymes. One or both of the ribozymes may be used together or separately with equal efficiency. The ribozymes possess a sequence region with a catalytic core that provides the attributed catalytic activity to these ribozymes.