Whole-body mathematical model for simulating intracranial pressure dynamics

US7182602B2 · kind B2 · utility

Assignee

• University of Vermont and State Agricultural College · US

Inventors

• William D. Lakin · Johnson, US
• Paul L. Penar · Shelburne, US
• Scott A. Stevens · Downers Grove, US
• Bruce I. Tranmer · Burlington, US

Key dates

• Filing date: Sep 9, 2003
• Grant date: Feb 27, 2007
• Expiry date: Oct 28, 2024

Classification

• Technology area (CPC G): Physics
• CPC primary: G09B23/28
• WIPO field: Control
• WIPO sector: Instruments

Abstract

A whole-body mathematical model (10) for simulating intracranial pressure dynamics. In one embodiment, model (10) includes 17 interacting compartments, of which nine lie entirely outside of intracranial vault (14). Compartments (F) and (T) are defined to distinguish ventricular from extraventricular CSF. The vasculature of the intracranial system within cranial vault (14) is also subdivided into five compartments (A, C, P, V, and S, respectively) representing the intracranial arteries, capillaries, choroid plexus, veins, and venous sinus. The body's extracranial systemic vasculature is divided into six compartments (I, J, O, Z, D, and X, respectively) representing the arteries, capillaries, and veins of the central body and the lower body. Compartments (G) and (B) include tissue and the associated interstitial fluid in the intracranial and lower regions. Compartment (Y) is a composite involving the tissues, organs, and pulmonary circulation of the central body and compartment (M) represents the external environment.