Cell regulatory genes, encoded products, and uses related thereto

US7183049B1 · kind B1 · utility

Assignee

• President and Fellows of Harvard College · US

Inventors

• Annie Yang · La Mirada, US
• Frank McKeon · Boston, US

Key dates

• Filing date: Oct 15, 1998
• Grant date: Feb 27, 2007
• Expiry date: Oct 15, 2018

Classification

• Technology area (CPC —): General

Abstract

This application describes the cloning of p63, a gene at chromosome 3q27-29, that bears homology to the tumor suppressor p53. The p63 gene encodes at least six different isotypes. p63 was detected in a variety of human and mouse tissue and demonstrates remarkably divergent activities, such as the ability to transactivate p53 reporter genes and induce apoptosis. Isotopes of p63 lacking a transactivation domain act as dominant negatives towards the transactivation by p53 and p63.