Inhibition of Aβ production by β-secretase BACE2
US7183070B2 · kind B2 · utility
36Cited by
6References
7Claims
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Assignee
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Key dates
| Filing date | Dec 31, 2003 |
| Grant date | Feb 27, 2007 |
| Priority date | — |
| Expiry date | Apr 9, 2024 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/04
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention is based on the findings that BACE2, a homolog of β-secretase BACE, is able to stimulate processing of APP in a non-amyloidogenic pathway, thereby suppressing the level of Aβ. Accordingly, the present invention provides methods and means for the identification and use of modulators of this unique activity of BACE2 to suppress Aβ production. The compounds identified using the methods and means provided herein may be used as potential candidates for the treatment of Alzheimer's disease and other neurological diseases by reducing β-amyloid deposit formation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.