Cytotoxin-based biological containment
US7183097B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | May 7, 1999 |
| Grant date | Feb 27, 2007 |
| Priority date | — |
| Expiry date | May 7, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N15/68
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Method of conditionally controlling the survivability of a recombinant cell population and of containing such cells to an environment or containing replicons to a host cell is based on the use of proteic killer systems including the E. coli relBE locus and similar systems found in Gram-negative and Gram-positive bacteria and Archae. Such system are generally based on a cytotoxin polypeptide and an antitoxin or antidote polypeptide that in contrast to the cytotoxin is degradable by proteases. The recombinant cells are useful as vaccines, pollulant degrading organisms or as biogical pest control organisms e.g. expressing B. thuringiensis crystalline proteins.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.