Compounds and methods to increase plasma HDL cholesterol levels and improve HDL functionality
US7183317B2 · kind B2 · utility
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14References
9Claims
0Family size
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Key dates
| Filing date | Jul 8, 2004 |
| Grant date | Feb 27, 2007 |
| Priority date | — |
| Expiry date | Jul 8, 2024 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/044
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
It has been discovered that certain selected ethers of probucol, and their pharmaceutically acceptable salts or prodrugs, are useful for increasing circulating HDL cholesterol. These compounds may also improve HDL functionality by (a) increasing clearance of cholesteryl esters, (b) increasing HDL-particle affinity for hepatic cell surface receptors or (c) increasing the half life of apoAI-HDL.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.