Neural stem cells and use thereof for brain tumor therapy

US7186409B2 · kind B2 · utility

Assignees

• Children's Medical Center Corporation · US
• The General Hospital Corporation · US
• Northeastern Ohio Universities College of Medicine · US

Inventors

• Evan Snyder · Village of La Jolla, US
• Xandra O. Breakefield · Newton, US
• Karen Aboody · Arcadia, US
• Ulrich Herrlinger · Lörrach, DE
• William P. Lynch · Honeoye Falls, US

Key dates

• Filing date: Feb 28, 2001
• Grant date: Mar 6, 2007
• Expiry date: Feb 28, 2021

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention is based upon a surprising finding that stem cells, more particularly neural stem cells, can migrate throughout a brain tumor and track metastatic brain tumor cells. The invention provides a method for treating brain tumors by administering genetically engineered neural stem cells in an individual affected by brain tumors. The invention also provides a method of preparing genetically engineered neural stem cells and a composition comprising genetically engineered neural stem cells in a pharmaceutically acceptable carrier.