Alpha(2) macroglobulin receptor as a heat shock protein receptor and uses thereof
US7186515B1 · kind B1 · utility
2Cited by
16References
27Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 25, 2000 |
| Grant date | Mar 6, 2007 |
| Priority date | — |
| Expiry date | Jul 25, 2020 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/02
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention relates to the use of alpha (2) macroglobulin (“α2M”) receptor as a heat shock protein receptor, cells that express the α2M receptor bound to an HSP, and antibodies and other molecules that bind the α2M receptor-HSP complex. The invention also relates to screening assays to identify compounds that modulate the interaction of an HSP with the α2M receptor, and methods for using compositions comprising α2M-receptor sequences for the diagnosis and treatment of immune disorders, proliferative disorders, and infectious diseases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.