Aryl imidazoles and related compounds as C5a receptor modulators
US7186734B2 · kind B2 · utility
4Cited by
9References
36Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 28, 2003 |
| Grant date | Mar 6, 2007 |
| Priority date | — |
| Expiry date | Feb 15, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D417/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides Aryl substituted imidazoles, pyrazoles, pyridizines and related compounds of the Formulawhere the variables are defined herein.Such compounds are ligands of C5a receptors. Preferred compounds of the invention act bind to C5a receptors with high affinity and exhibit neutral antagonist or inverse agonist activity at C5a receptos. This invention also relates to pharmaceutical compositions comprising such compounds. It further relates to the use of such compounds in treating a variety of inflammatory and immune system disorders.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.