Process for the preparation of 2-[(diphenylmethyl) thio] acetamide
US7186860B2 · kind B2 · utility
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23Claims
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Key dates
| Filing date | Jan 30, 2004 |
| Grant date | Mar 6, 2007 |
| Priority date | — |
| Expiry date | Jan 30, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C315/02
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Process for the preparation of 2-[(diphenylmethyl)thioacetamide, an intermediate for the preparation of Modafinil which is a CNS stimulant and used for the treatment of narcolepsia. The process comprises reacting 2-[(diphenylmethyl)thio]acetic acid with alcohols, in presence of catalytic amount of inorganic acid or organic acid at reflux temperature of alcohol to obtain corresponding ester which is reacted with ammonia to give 2-[(diphenylmethyl)thio]acetamide. If desired 2-[(diphenylmethyl)thioacetamide thus produced is reacted with hydrogen peroxide to produce Modafinil.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.