Method of in vitro preconditioning healthy donor's myoblasts before transplantation thereof in compatible patients suffering of myopathies like muscular dystrophy, for improving transplantation success
US7189391B2 · kind B2 · utility
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3References
4Claims
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Key dates
| Filing date | Mar 21, 2002 |
| Grant date | Mar 13, 2007 |
| Priority date | — |
| Expiry date | Mar 21, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2510/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods of pre-treating healthy donor's myoblast cultures with growth or trophic factors on transplantation into subjects suffering from myopathic conditions such as muscular dystrophy. Compositions comprising myoblasts and fusion-promoting metalloproteases can be transplanted. Alternatively, myoblasts can be transplanted along with an agent inducing the expression of a fusion-promoting metalloprotease, or a composition comprising genetically-modified myoblasts capable of expressing a fusion-promoting metalloprotease can be transplanted.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.