Controlled release oral drug delivery system

US7189414B2 · kind B2 · utility

Assignee

• YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. · IL

Inventors

• Abraham Rubinstein · Jerusalem, IL
• Michael Friedman · Jerusalem, IL
• Muhammad Baluom · Taibe, IL
• Boaz Tirosh · Rehovot, IL

Key dates

• Filing date: Jul 31, 2003
• Grant date: Mar 13, 2007
• Expiry date: Aug 29, 2023

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/2013
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to synchronous drug delivery composition comprising a polymeric matrix which comprises hydrogel blended with a hydrophobic polymer, so as to form an erodible matrix, a drug, and, optionally, an agent which enhances intestinal drug absorption and/or an agent which inhibits intestinal drug degradation,wherein erosion of the erodible matrix, permits synchronous release of the drug, the hydrogel and the intestinal drug absorption agent and/or the agent which inhibits intestinal drug degradation.