Peptides and peptidomimetics with structural similarity to human p53 that activate p53 function

US7189801B2 · kind B2 · utility

Assignees

• The Wistar Institute · US
• BAYER HEALTHCARE LLC · DE

Inventors

• Thanos Halazonetis · Philadelphia, US
• Wolfgang Hartwig · Wuppertal, DE

Key dates

• Filing date: Jun 4, 2002
• Grant date: Mar 13, 2007
• Expiry date: Oct 12, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K14/82
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides peptides and peptidomimetics corresponding to part or to the entirety of the region encompassed by residues 360–386 of human p53, said peptides and peptidomimetics characterized by the ability to activate DNA binding of wild-type p53 and of select tumor-derived p53 mutants. Pharmaceutical compositions of the compounds of the invention and methods of using these compositions therapeutically are also provided.