Glycosulfopeptide inhibitors of leukocyte rolling and methods of use thereof
US7189828B2 · kind B2 · utility
3Cited by
16References
6Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 29, 2005 |
| Grant date | Mar 13, 2007 |
| Priority date | — |
| Expiry date | Sep 29, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/70596
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compounds, compositions and methods for treating conditions characterized by leukocyte rolling are described. The compounds contain glycosulfopeptide structures comprising sulfated tyrosines and sialyated, fucosylated N-acetyllactosamino glycans. The glycosulfopeptides may be conjugated or complexed to other compounds for enhancing serum half-life or for controlled release, for example. Examples of conditions treated include inflammation, ischemia-reperfusion injury, rheumatoid arthritis, atherosclerosis, leukocyte-mediated lung injury, restenosis, and thrombosis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.