Compositions of somatostatin analogues
US7192570B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Aug 7, 2002 |
| Grant date | Mar 20, 2007 |
| Priority date | — |
| Expiry date | Aug 16, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/655
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
In one embodiment, a composition of somatostatin analogues having the general formula:is provided wherein Z may be absent or present and when present is selected from DOTA- and DTPA-based chelators, NOTA-based chelators, carbonyl compounds, hydrazino nicotinamide, N4-chelators, desferrioxamine, NxSy-chelators, optionally complexed or labeled with a radioisotope, tyrosine for halogenation, a fluorescent dye, or biotin. The composition further provides that L may or may not be present and when present is a linker molecule, X1 is glutamic acid or a symmetric or asymmetric diamino acid containing 3 or 4 consecutive C atoms, X2 is a positively charged natural or unnatural amino acid, an arginine mimic, citrulline, or a neutral amino acid, X3 is phenylalanine, Ala-[3-(2-thienyl)], α-naphthylalanine, or β-naphthylalanine, X4 is an aromatic amino acid, X5 is threonine or serine, and X6 is phenylalanine, Ala-[3-(2-thienyl)], α-naphthylalanine, or β-naphthylalanine.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.