Method of reducing neuronal electrical activity with a potassium channel subunit
US7192773B2 · kind B2 · utility
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Key dates
| Filing date | May 15, 2003 |
| Grant date | Mar 20, 2007 |
| Priority date | — |
| Expiry date | Apr 15, 2024 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K48/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods of reducing the excitability of an excitable cell by transforming an excitable cell with a nucleic acid construct encoding an open rectifier K+ channel (dORK) (SEQ ID NO:2) or a modified open rectifier K+ channel (dORKΔ) (SEQ ID NO:4), and expressing the open rectifier K+ channel in the excitable cell, wherein the excitability of the transformed cell is reduced. Also featured are transgenic animals expressing dORK or dORKΔ.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.