Process for production of crystals of 11μ-benzaldoxim-estra-4,9-diene derivatives, crystals obtained thereby and pharmaceutical preparations containing them

US7192942B2 · kind B2 · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Detlef Grawe · Kleinromstedt, DE
• Hagen Gerecke · Jena, DE
• Peter Hoesel · Jena, DE
• Annette Eichardt · Jena, DE
• Sabine Gliesing · Jena, DE
• Uwe Mueller · Jena, DE

Key dates

• Filing date: Apr 17, 2003
• Grant date: Mar 20, 2007
• Expiry date: Apr 9, 2024

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The process for making crystals of a 11 β-benzaldoxim-estra-4,9-diene derivative having an average particle size of from 3 μm to 25 μm and a maximum particle size of 100 μm, includes subjecting a supersaturated solution containing a special 11β-benzaldoxim-estra-4,9-diene derivative of formula (I) to a wet milling by a wet milling apparatus while crystallizing, In order to obtain a primary particle suspension. Crystals obtained according to this process and pharmaceutical preparations containing them are also described and are part of the invention.