Peptides derivatives comprising thiazepine group for the treatment of hyperlipidemic conditions

US7192947B2 · kind B2 · utility

Assignee

• ASTRAZENECA AB · SE

Inventors

• Ingemar Starke · Gothenburg, SE
• Mikael Dahlstrom · Timrå, SE
• Suzanne Alenfalk · Hultsfred, SE
• Tore Skjaret · Hultsfred, SE
• Malin Lemurell · Mölndal, SE

Key dates

• Filing date: Jun 10, 2003
• Grant date: Mar 20, 2007
• Expiry date: Jun 10, 2023

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds of formula (I): (wherein variable groups are as defined within) pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as ileal bile acid transport (IBAT) inhibitors for the treatment of hyperlipidaemia. Process for their manufacture and pharmaceutical compositions containing them are also described