Methods of treating hormone-related conditions using cyclothiocarbamate derivatives

US7192956B2 · kind B2 · utility

Assignee

• Wyeth, LLC · US

Inventors

• Andrew Fensome · Wayne, US
• Gary S. Grubb · Newtown Square, US
• Diane D. Harrison · Villanova, US
• Richard Craig Winneker · Penllyn, US
• Puwen Zhang · Audubon, US
• Jeffrey Kern · Gilbertsville, US
• Eugene A. Terefenko · Quakertown, US

Key dates

• Filing date: Jun 23, 2003
• Grant date: Mar 20, 2007
• Expiry date: Jun 23, 2023

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides methods of inducing contraception which includes delivering to a female a composition containing a compound of formula I or formula II, or tautomers thereof, in a regimen which involves delivering one or more of a selective estrogen receptor modulator, wherein formula I is:and wherein R1–R5 and Q1 are defined as described herein. Methods of providing hormone replacement therapy and for treating carcinomas, dysfunctional bleeding, uterine leiomyomata, endometriosis, and polycystic ovary syndrome is provided which includes delivering a compound of formula I and a selective estrogen receptor modulator are also described.