Cyclic imide-substituted pyridylalkane, alkene, alkine carboxamides useful as cytostatic and immunosuppressive agents

US7192967B1 · kind B1 · utility

Assignee

• ASTELLAS PHARMA INC. · JP

Inventors

• Elfi Biedermann · Vaterstetten, DE
• Max Hasmann · Schwanau, DE
• Roland Loser · Feldafing, DE
• Benno Rattel · Munich, DE
• Friedemann Reiter · Putzbrunn, DE
• Barbara Schein · Neufahrn, DE
• Klaus Seibel · Gräfelfing, DE
• Klaus Vogt · Munich, DE
• Katia Wosikowski · Poing, DE
• Isabel Schemainda · Munich, DE

Key dates

• Filing date: Jun 16, 2000
• Grant date: Mar 20, 2007
• Expiry date: Aug 28, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to new pyridylalkane, alkene, and alkine carboxamides substituted with an imide with a saturated or one or several-fold unsaturated hydrocarbon residue in the carboxylic acid group according to general formula (I), wherein the residue E is a cyclic imide, methods for the production of these compounds, medicaments containing these and their production as well as their therapeutic use, especially as cytostatic agents and immunosuppressive agents, for example in the treatment or prevention of various types of tumors, inhibition of abnormal cell growth and control of immune reactions, for example autoimmune diseases.