Protease inhibitor conjugates and antibodies useful in immunoassay

US7193065B2 · kind B2 · utility

Assignee

• Roche Diagnostics Operations, Inc. · US

Inventors

• Gerald Sigler · Carmel, US
• Raymond Hui · Indianapolis, US
• Ina Deras · San Diego, US
• Richard Root · Fishers, US
• Mitali Ghoshal · Noblesville, US
• Erasmus Huber · Garching bei München, DE
• Herbert von der Eltz · Spaichingen, DE
• Sigrun Metz · Munich, DE
• Peter Kern · Penzberg, DE

Key dates

• Filing date: Sep 24, 2003
• Grant date: Mar 20, 2007
• Expiry date: Aug 15, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K16/44
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Activated haptens useful for generating immunogens to HIV protease inhibitors, immunogens useful for producing antibodies to HIV protease inhibitors, and antibodies and labeled conjugates useful in immunoassays for HIV protease inhibitors. The novel haptens feature an activated functionality at the central, non-terminal hydroxyl group common to all HIV protease inhibitors, e.g., saquinavir, nelfinavir, indinavir, amprenavir, ritonavir, lopinavir, and atazanavir.