Sequences upstream of the CARP gene, vectors containing them and uses thereof
US7193075B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Dec 7, 2001 |
| Grant date | Mar 20, 2007 |
| Priority date | — |
| Expiry date | Dec 7, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2830/85
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to novel promoter sequences derived from a portion upstream of the coding sequence of the gene for the CARP protein (Cardiac Ankyrin Repeat Protein), and which are capable of controlling the level and the specificity of expression of a transgene in vivo in cardiac muscle cells. The invention thus describes novel compositions, constructs, vectors and their uses in vivo for the transfer and expression of a nucleic acid in vivo in cardiac muscle cells. The subject of the present invention is also the use of the promoter sequences for generating transgenic animals which constitute models for studying certain cardiac pathologies.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.