Process for manufacture of telmisartan

US7193089B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Norbert Hauel · Schemmerhofen, DE
• Rolf Dach · Gau-Algesheim, DE
• Helmut Heitger · Ingelheim am Rhein, DE
• Oliver Meyer · Ingelheim am Rhein, DE

Key dates

• Filing date: Mar 17, 2004
• Grant date: Mar 20, 2007
• Expiry date: Jul 15, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D235/18
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for preparing telmisartan by reacting 2-n-propyl-4-methyl-6-(1′-methylbenzimidazol-2′-yl)benzimidazole with a compound of formula (IV)wherein Z is a leaving group, to obtain the compound 2-cyano-4′-[2″-n-propyl-4″-methyl-6″-(1′″-methylbenzimidazol-2′″-yl)benzimidazol-1″-ylmethyl]biphenyl, and subsequently hydrolyzing the nitrile function to obtain the acid function.