Screening systems and methods for identifying modulators of xenobiotic metabolism
US7193125B2 · kind B2 · utility
0Cited by
5References
10Claims
0Family size
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Key dates
| Filing date | Aug 15, 2002 |
| Grant date | Mar 20, 2007 |
| Priority date | — |
| Expiry date | Jun 27, 2023 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA01K2267/0393
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides mice having reduced CAR receptor activity and mice expressing a human CAR receptor. These mice are useful in screening methods to identify compounds that modulate CAR receptor activity, compounds likely to have CAR-mediated toxicity, and analogs of these compounds with less potential toxicity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.