Humanized antibodies that sequester abeta peptide

US7195761B2 · kind B2 · utility

Assignees

• ELI LILLY AND COMPANY · US
• Washington University · US

Inventors

• David Holtzman · Chesterfield, US
• Ronald DeMattos · Noblesville, US
• Kelly R. Bales · Indianapolis, US
• Steven M. Paul · Carmel, US
• Naoya Tsurushita · Palo Alto, US
• Maximiliano Vasquez · Palo Alto, US

Key dates

• Filing date: Aug 22, 2002
• Grant date: Mar 27, 2007
• Expiry date: Aug 22, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method to treat conditions characterized by formation of amyloid plaques both prophylactically and therapeutically is described. The method employs humanized antibodies which sequester soluble Aβ peptide from human biological fluids or which preferably specifically bind an epitope contained within position 13–28 of the amyloid beta peptide Aβ.