Diagnosis of diseases associated with gene regulation

US7195870B2 · kind B2 · utility

Assignee

• EPIGENOMICS AG · DE

Inventors

• Alexander Olek · Berlin, DE
• Christian Piepenbrock · Berlin, DE
• Kurt Berlin · Stahnsdorf, DE

Key dates

• Filing date: Apr 6, 2001
• Grant date: Mar 27, 2007
• Expiry date: Aug 12, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/156
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Chemically modified genomic sequences of genes associated with gene regulation, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genes associated with gene regulation which are directed against the sequence are disclosed. In addition, a method for ascertaining genetic and/or epigenetic parameters of genes associated with gene regulation is disclosed.