Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US7196059B2 · kind B2 · utility
3Cited by
178References
34Claims
0Family size
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Key dates
| Filing date | Mar 5, 2003 |
| Grant date | Mar 27, 2007 |
| Priority date | — |
| Expiry date | Mar 5, 2023 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/60
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Pharmaceutical compositions that include insulin, an insulin drug-oligomer conjugate, a fatty acid component, and a bile salt component or a bile salt component without a fatty acid component are described. The insulin drug is covalently coupled to an oligomeric moiety. The fatty acid component and the bile salt component, when together, can be present in a weight-to-weight ratio of between 1:15 and 15:1. Methods of treating an insulin deficiency in a subject in need of such treatment using such pharmaceutical compositions are also provided, as are methods of providing such pharmaceutical compositions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.