Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same
US7196180B2 · kind B2 · utility
91Cited by
36References
13Claims
0Family size
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Key dates
| Filing date | Oct 6, 2003 |
| Grant date | Mar 27, 2007 |
| Priority date | — |
| Expiry date | Oct 6, 2023 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2533/80
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods for chemical modification of hyaluronic acid, formation of amine or aldehyde functionalized hyaluronic acid, and the cross-linking thereof to form hydrogels are provided. Functionalized hyaluronic acid hydrogels of this invention can be polymerized in situ, are biodegradable, and can serve as a tissue adhesive, a tissue separator, a drug delivery system, a matrix for cell cultures, and a temporary scaffold for tissue regeneration.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.