Preparation of Anilineboronic acids and derivatives thereof

US7196219B2 · kind B2 · utility

Assignee

• Archimica, Inc. · US

Inventors

• Stefan Scherer · Büttelborn, DE
• Andreas Meudt · Hofheim, DE
• Bernd Wilhelm Lehnemann · Cologne, DE
• Alexei Kalinin · Kingston, CA
• Victor Snieckus · Waterloo, CA

Key dates

• Filing date: May 14, 2004
• Grant date: Mar 27, 2007
• Expiry date: Jun 8, 2025

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for preparing anilineboronic acid derivative of the formula I,by converting an aniline to a diprotected aniline by introducing two protecting groups, metalating the diprotected aniline with a metalating agent and simultaneously or subsequently reacting with a boronic ester B(OR1,2,3)3 to form a protected anilineboronic ester, which is converted, by detaching the protecting groups, to the anilineboronic esters of the formula (I).