Compositions and methods for the generation of protective immune responses against malaria

US7198791B2 · kind B2 · utility

Assignee

• Pluschke, Gerd et al. · DE

Inventors

• Gerd Pluschke · Annaberg-Buchholz, DE
• Mueller Markus · Lörrach, DE
• John Robinson · Spanish Fork, US
• Rinaldo Zurbriggen · Davos, CH
• Annabelle Freund-Renard · Schönenwerd, CH

Key dates

• Filing date: Mar 3, 2003
• Grant date: Apr 3, 2007
• Expiry date: Apr 25, 2023

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention presents vaccine formulations comprising highly antigenic epitopes identified within the semi-conserved loop-I of domain III that are capable of eliciting parasite growth inhibitory antibodies. The cyclized or linear peptides can be applied by known adjuvants or be encapsulated by or attached onto the surface of liposomes or virosomes (IRIVs) which serve as human compatible antigen delivery systems. Both cyclized and linear versions of the peptide antigens are surprisingly effective in eliciting immune responses that are cross-reactive with parasite-expressed AMA-1.